Abstract
A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A2a and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A2a receptor on the human neutrophil.
MeSH terms
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Adenosine / analogs & derivatives
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Adenosine / chemistry*
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Adenosine / pharmacology*
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Anti-Inflammatory Agents / chemistry
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GTP-Binding Proteins
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Purinergic P1 Receptor Agonists*
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Solubility
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents
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Purinergic P1 Receptor Agonists
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GTP-Binding Proteins
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Adenosine